7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline
Varenicline
CAS: 249296-44-4
Molecular Formula: C13H13N3
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline - Names and Identifiers
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline - Physico-chemical Properties
| Molecular Formula | C13H13N3 |
| Molar Mass | 211.26 |
| Density | 1.247±0.06 g/cm3(Predicted) |
| Melting Point | 138.5 °C |
| Boling Point | 400.6±40.0 °C(Predicted) |
| pKa | 9.60±0.20(Predicted) |
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline - Reference Information
| Introduction | Vareniclin is a nicotinic acetylcholine receptor partial agonist used to quit smoking. Vareniclin leads to a low incidence of elevated serum enzymes, which rarely leads to clinically significant acute liver injury since approval for widespread use. |
| Mechanism of action | Vareniclin is a partial agonist of α4β2-nicotinic acetylcholine receptor, which prevents nicotine (nicotine) from binding to α4β2-nicotinic acetylcholine receptor, and at the same time supplies some agonists, thereby reducing the craving for nicotine. The use of varenklin during the smoking cessation course can increase the success rate of smoking cessation and reduce recurrence. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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